THE EFFECT OF MEDROXYPROGESTERONE ACETATE ON LEARNING AND MEMORY IN OVARY-INTACT MICE

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2020-05

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Medroxyprogesterone Acetate (MPA) is birth control that is used for contraception and hormone therapy (Seven et al., 2014). MPA is considered to be an ideal birth control option for adolescents because of its convenient administration and fast onset (Rickert et al., 2006). While there are studies that indicate detriments in spatial memory in ovariectomized or older rats following administration of MPA (Braden et al., 2011), there is limited research investigating the effects of MPA in young ovary-intact mice. The goal of this project was to assess if the effects of progestin previously described are apparent in an ovary-intact population. Behavioral assays measured anxiety-like behavior, spatial memory, and activities of daily living. Despite no significant findings in these measures, this study provides a stepping point for investigating this compound/birth control in a population of ovary-intact animals.

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